A COX-2 inhibitor; 10-fold selective for COX-2 over COX-1; reduces LPS-induced PGE2 production in bovine arterial endothelial cells (IC50 = 1 μM); reduces vascular permeability

Feprazone – 25 mg

Brand:
Cayman
CAS:
30748-29-9
Storage:
-20
UN-No:
Non-Hazardous - /

Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.{48049} It reduces LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in bovine arterial endothelial cells (IC50 = 1 μM). Oral administration of feprazone (25-100 mg/kg) reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis.{48050}  

 

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Description

A COX-2 inhibitor; 10-fold selective for COX-2 over COX-1; reduces LPS-induced PGE2 production in bovine arterial endothelial cells (IC50 = 1 μM); reduces vascular permeability, edema, and nociception in a rat model of adjuvant-induced arthritis from 25-100 mg/kg

Formal name: 4-(3-methyl-2-buten-1-yl)-1,2-diphenyl-3,5-pyrazolidinedione

Synonyms: 

Molecular weight: 320.4

CAS: 30748-29-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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