A fibrate that acts as a lipid-lowering agent

Fenofibric Acid – 10 g

Brand:
Cayman
CAS:
42017-89-0
Storage:
4
UN-No:
Non-Hazardous - /

Fenofibric acid is a fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides.{31212} It displays high affinity for liver fatty acid binding protein (Ki = 24 nM).{23622} Fenofibric acid increases plasma apolipoprotein A-II via the response element for peroxisome proliferator-activated receptors (PPARs), although it has very low affinity for PPARs (IC50s > 100 µM for both human PPARα or PPARγ).{31213,31212} However, in a transactivation assay, it exhibits EC50 values of 18 and 30 µM for mouse and human PPARα, respectively.{10670} Fenofibric acid, when combined with statins, has been shown to be effective against mixed dyslipidemia in clinical trials.{31211}  

 

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Description

A fibrate that acts as a lipid-lowering agent, decreasing low-density lipoprotein cholesterol and triglycerides; displays high affinity for L-FABP (Ki = 24 nM); exhibits EC50 values of 18 and 30 µM for murine and human PPARα, respectively, in a transactivation assay

Formal name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid

Synonyms:  FNF Acid|NSC 281318

Molecular weight: 318.8

CAS: 42017-89-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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