An NSAID and a prodrug form of 4-biphenylacetic acid; inhibits collagen-induced platelet aggregation in vitro at 125 μg/ml; suppresses UV-induced erythema in guinea pigs from 8-250 mg/kg; reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg); reduces inflammation in a rat model of adjuvant-induced arthritis at 28 mg/kg; reduces yeast-induced fever in rats

Fenbufen – 5 g

Brand:
Cayman
CAS:
36330-85-5
Storage:
-20
UN-No:
Non-Hazardous - /

Fenbufen is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of 4-biphenylacetic acid.{52083} Fenbufen (125 μg/ml) inhibits collagen-induced, but not arachidonate-induced, platelet aggregation in vitro.{52084} In vivo, fenbufen (8-250 mg/kg) suppresses UV-induced erythema in guinea pigs.{52083} It reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg).{52084} Fenbufen (28 mg/kg) reduces inflammation in a rat model of adjuvant-induced arthritis. It also reduces yeast-induced fever in rats. Formulations containing fenbufen were previously used in the treatment of osteoarthritis and inflammatory pain.  

 

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Description

An NSAID and a prodrug form of 4-biphenylacetic acid; inhibits collagen-induced platelet aggregation in vitro at 125 μg/ml; suppresses UV-induced erythema in guinea pigs from 8-250 mg/kg; reduces phenylquinone-induced writhing in mice (ED50 = 7.7 mg/kg) and brewer’s yeast-induced mechano-allodynia in rats (ED50 = 29 mg/kg); reduces inflammation in a rat model of adjuvant-induced arthritis at 28 mg/kg; reduces yeast-induced fever in rats

Formal name: γ-oxo-[1,1′-biphenyl]-4-butanoic acid

Synonyms:  CL 82204

Molecular weight: 254.3

CAS: 36330-85-5

Purity: ≥98%

Formulation: A crystalline solid

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