Description
An inhibitor of NMDA receptors and a modulator of GABAA receptors; has broad-spectrum inhibitory activity against excitatory amino acid receptors; binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 µM in the resting, activated, and desensitized states, respectively; inhibits NMDA currents in a use-dependent manner; a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes; a negative modulator of α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes; inhibits seizures induced by maximal electroshock, pentylenetetrazole, and picrotoxin in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively)
Formal name: 2-phenyl-1,3-propanediol 1,3-dicarbamate
Synonyms: ADD 03055
Molecular weight: 238.2
CAS: 25451-15-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders
