A δ lactone with anticancer activity; cytotoxic to adriamycin-susceptible P388

FD-211 – 1 mg

Brand:
Cayman
CAS:
162341-24-4
Storage:
-20
UN-No:
Non-Hazardous - /

FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.{53330} It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 µg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 µg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 µg/ml for all).  

 

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SKU: 28060 - 1 mg Category:

Description

A δ lactone with anticancer activity; cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 µg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 µg/ml); inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 µg/ml for all)

Formal name: (2R,3R,7S,7aR)-2,3,7,7a-tetrahydro-3-hydroxy-2,7-di-(1E)-1-propen-1-yl-5H-furo[3,4-b]pyran-5-one

Synonyms:  (–)-Waol A

Molecular weight: 236.3

CAS: 162341-24-4

Purity: ≥70%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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