An inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) which also blocks HIV-induced cytopathogenicity (EC50 = 73 nM)

FC 131 – 5 mg

Brand:
Cayman
CAS:
606968-52-9
Storage:
-20
UN-No:
Non-Hazardous - /

C-X-C chemokine receptor 4 (CXCR4) is a receptor for the stromal cell-derived factor-1 (SDF-1) which is designated as chemokine ligand 12 (CXCL12). It is involved in cell progression, hematopoiesis, cancer, HIV entry, and rheumatoid arthritis.{15449,16830,21624} FC 131 is an inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) and also blocks HIV-induced cytopathogenicity (EC50 = 73 nM).{21624} FC 131 derivatives can be used for imaging CXCR4 and elucidating its function.{21625}  

 

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SKU: 11960 - 5 mg Category:

Description

An inhibitor of CXCR4 activation by SDF-1 (IC50 = 4.5 nM) which also blocks HIV-induced cytopathogenicity (EC50 = 73 nM)

Formal name: cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]

Synonyms: 

Molecular weight: 729.8

CAS: 606968-52-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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