An inhibitor of glucose transport; partially inhibits glucose uptake in U937 and DU145 cells at 15-80 µM; sensitizes PPC-1 prostate cancer and U937 leukemia cells to FAS-induced cell death; also increases the expression of AspSyn and PCK2 at 50 µM; halts the cell cycle at the G0/G1 phase in U937 cells at 40 µM

Fasentin – 5 mg

Brand:
Cayman
CAS:
392721-37-8
Storage:
-20
UN-No:
Non-Hazardous - /

Fasentin is an inhibitor of glucose transport.{43670} It partially inhibits glucose uptake in U937 and DU145 cells when used at concentrations ranging from 15 to 80 µM. Fasentin sensitizes PPC-1 prostate cancer and U937 leukemia cells, but not DU145 prostate cancer cells, to cell death induced by the Fas receptor activator CH-11 activating anti-Fas antibody (FAS). It also increases the expression of AspSyn and PCK2, genes associated with glucose deprivation, in PPC-1 cells and halts the cell cycle at the G0/G1 phase in U937 cells when used at concentrations of 50 and 40 µM, respectively.  

 

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SKU: 27050 - 5 mg Category:

Description

An inhibitor of glucose transport; partially inhibits glucose uptake in U937 and DU145 cells at 15-80 µM; sensitizes PPC-1 prostate cancer and U937 leukemia cells to FAS-induced cell death; also increases the expression of AspSyn and PCK2 at 50 µM; halts the cell cycle at the G0/G1 phase in U937 cells at 40 µM

Formal name: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-butanamide

Synonyms: 

Molecular weight: 279.6

CAS: 392721-37-8

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Metabolism

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