An isoprenoid with diverse biological activities; an intermediate in the mevalonate biosynthesis pathway; an agonist at PPARα and PPARγ (ED50s = 5.5 and 28 µM

Farnesyl Alcohol – 5 g

Brand:
Cayman
CAS:
4602-84-0
Storage:
-20
UN-No:
Excepted Quantity - 3082 / 9

Farnesyl alcohol is an isoprenoid originally isolated from plants but also produced in mammals, including humans, as an intermediate in the mevalonate biosynthesis pathway.{39250} It acts as an agonist at the peroxisome proliferator-activated receptors PPARα and PPARγ (ED50s = 5.5 and 28 µM, respectively).{39249} Farnesyl alcohol has broad anticancer properties in vitro and in xenograft mouse models, inhibiting proliferation, slowing tumor growth, and inducing apoptosis.{39246,39245,39247} In addition, it acts as a quorum sensing molecule in fungi, including C. albicans, where it reduces virulence by blocking the transition from yeast to mycelium.{39244,39248}  

 

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Description

An isoprenoid with diverse biological activities; an intermediate in the mevalonate biosynthesis pathway; an agonist at PPARα and PPARγ (ED50s = 5.5 and 28 µM, respectively); inhibits proliferation, slows tumor growth, and induces apoptosis; acts as a quorum sensing molecule and reduces virulence in C. albicans,

Formal name: 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol

Synonyms:  Farnesol|FCI 119a|NSC 60597

Molecular weight: 222.4

CAS: 4602-84-0

Purity: ≥98% (mixture of isomers)

Formulation: A neat oil

Product Type|Biochemicals|Lipids|Prenol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases||Research Area|Infectious Disease|Quorum Sensing||Research Area|Lipid Biochemistry|Prenol Lipids

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