An alkaloid; inhibits sheep COX activity and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells (IC50s = 129 and 3.7 µM

Fangchinoline – 100 mg

Brand:
Cayman
CAS:
436-77-1
Storage:
-20
UN-No:
Non-Hazardous - /

Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties.{52160,52161,52162} It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 µM, respectively.{52160} Fangchinoline (1 and 10 µM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons.{52161} It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 µM, respectively.{52162} Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.  

 

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SKU: 29243 - 100 mg Category:

Description

An alkaloid; inhibits sheep COX activity and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells (IC50s = 129 and 3.7 µM, respectively); reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons at 1 and 10 µM; decreases proliferation of PC3 human prostate cancer cells by 63 and 86% at 20 and 30 µM, respectively; reduces tumor cell growth in a PC3 mouse xenograft model at 5 mg/kg per day for 12 days

Formal name: (4aS,16aS)-3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-22-ol

Synonyms:  7-O-Demethyltetrandrine|Hanfangchin B|NSC 77036

Molecular weight: 608.7

CAS: 436-77-1

Purity: ≥98%

Formulation: A crystalline solid

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