A plant defense polyacetylene; inhibits fatty acid biosynthesis in pathogens; binds to hCB1 and hCB2 receptors (Kis = 594 and 2

Falcarinol – 25 mg

Brand:
Cayman
CAS:
21852-80-2
Storage:
-20
UN-No:
- 1170 / 3

Falcarinol is a C17-polyacetylene produced by the Apiaceae family that has antimicrobial properties due to its inhibition of fatty acid biosynthesis.{38102,38105} Falcarinol binds to the human recombinant cannabinoid (CB) receptors, CB1 and CB2, (Kis = 594 and 2,100 nM, respectively) in an [3H]anandamide displacement assay in HEK293 cells.{38104} It differentially modulates synaptic and extrasynaptic GABAA receptors in a recombinant HEK293 system.{38101} In vitro assays of ATPase activity demonstrate that falcarinol inhibits breast cancer resistance protein ATP-binding cassette sub-family G member 2 (ABCG2; IC50 = 79.3 μM), a drug efflux transporter and mediator of drug resistance.{38106} Falcarinol (6.88 μg/g feed) also inhibits aberrant crypt foci by 26.6% in azoxymethane-induced rats.{38103}  

 

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Description

A plant defense polyacetylene; inhibits fatty acid biosynthesis in pathogens; binds to hCB1 and hCB2 receptors (Kis = 594 and 2,100 nM, respectively); modulates synaptic and extrasynaptic GABAA receptors; inhibits ATPase activity in ABCG2 (IC50 = 79.3 μM); inhibits aberrant crypt foci (26.6%) in azoxymethane-induced rats

Formal name: 1,9Z-heptadecadiene-4,6-diyn-3R-ol

Synonyms: 

Molecular weight: 244.4

CAS: 21852-80-2

Purity: ≥70%

Formulation: A solution in ethanol

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Multidrug Resistance||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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