A direct inhibitor of FAK1 autophosphorylation

FAK Inhibitor 14 – 50 mg

Brand:
Cayman
CAS:
4506-66-5
Storage:
-20
UN-No:
Non-Hazardous - /

Focal adhesion kinases (FAK) are non-receptor tyrosine kinases that play roles in regulating diverse processes, including cell adhesion, spreading, migration, proliferation, and apoptosis.{15630} They are over-expressed in many types of cancer. FAK inhibitor 14 is a direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 with an IC50 value of about 1 μM.{23133} There is no known significant effect on the activity of a range of other kinases. FAK inhibitor 14 promotes cell detachment and inhibits cell adhesion of cells in culture.{23133} Moreover, it blocks tumor growth in vivo.{23133,23132,23134} FAK inhibitor 14 has also been used to demonstrate a role for FAK in the regulation of aortic stiffness.{23131}  

 

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Description

A direct inhibitor of FAK1 autophosphorylation, blocking phosphorylation of Y397 (IC50 = 1 μM); no known significant effect on the activity of a range of other kinases; promotes cell detachment and inhibits cell adhesion of cells in culture; blocks tumor growth in vivo

Formal name: 1,2,4,5-benzenetetramine, tetrahydrochloride

Synonyms:  Focal Adhesion Kinase Inhibitor 14|NSC 667249|NSC 677249|Y15

Molecular weight: 284

CAS: 4506-66-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling||Research Area|Cardiovascular System|Vasculature

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