A non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase

Fadrozole (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
102676-31-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Fadrozole is a non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively).{38819,38820} It selectively inhibits estrogen over progesterone production induced by luteinizing hormone (LH) in hamster ovarian tissue as well as corticosterone and aldosterone production induced by adrenocorticotropic hormone (ACTH; Item No. 24257) in rat adrenal tissue (IC50s = 0.03, 160, 100, and 1 μM, respectively).{38819} It also decreases ovarian estrogen levels in rats when administered at a dose of 0.26 mg/kg.{38820} Fadrozole inhibits conversion of cholesterol to 27-hydroxycholesterol by the cytochrome P450 (CYP) isomer 27A1 (Ki = 4.6 μM).{38821} It inhibits growth of androstenedione-stimulated mammary D2 cells implanted into thoracic mammary fat pads of mice by 95% when administered at a dose of 0.5 mg per animal per day.{38822}  

 

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Description

A non-steroidal aromatase inhibitor (IC50s = 5 and 1.4 nM for human placental and rat ovarian microsomal aromatase, respectively); selectively inhibits LH-induced estrogen over progesterone production in hamster ovarian tissue as well as ACTH-induced corticosterone and aldosterone production in rat adrenal tissue (IC50s = 0.03, 160, 100, and 1 μM, respectively); decreases ovarian estrogen levels in rats (0.26 mg/kg); inhibits growth of androstenedione-stimulated mammary D2 cells implanted in mice by 95% (0.5 mg per animal per day) ,

Formal name: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile, monohydrochloride

Synonyms:  CGS 16949A

Molecular weight: 259.7

CAS: 102676-31-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids

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