A PAD inhibitor (IC50s = 29.5 and 350 µM for PAD1 and PAD3

F-Amidine (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
877617-46-4
Storage:
-20
UN-No:
De Minimis - 1230 / 3|6.1

F-amidine is an inhibitor of protein arginine deiminases (PADs) that is selective for PAD1 and PAD4 (IC50s = 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4 in vitro, respectively).{18132,19982} It irreversibly inactivates all four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1 by covalently modifying an active site cysteine that is important for its catalytic activity.{18132,36047} F-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).{18529}  

 

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SKU: 10610 - 1 mg Category:

Description

A PAD inhibitor (IC50s = 29.5 and 350 µM for PAD1 and PAD3, respectively, in vitro; irreversibly inactivates four PAD subtypes (kinact/KI = 2,800, 380, 170, and 3,000 M-1min-1); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively)

Formal name: N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-benzamide, 2,2,2-trifluoroacetate

Synonyms: 

Molecular weight: 408.4

CAS: 877617-46-4

Purity: ≥95%

Formulation: A solution in methanol

Product Type|Biochemicals|Small Molecule Inhibitors|Deiminases||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination

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