An internal standard for the quantification of ezetimibe by GC- or LC-MS

Ezetimibe-d4 – 1 mg

Brand:
Cayman
CAS:
1093659-89-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe (Item No. 16331) by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.{19679,15337} Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1.{19679,15337} Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.{19679,43023}  

 

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SKU: 25044 - 1 mg Category:

Description

An internal standard for the quantification of ezetimibe by GC- or LC-MS

Formal name: (3R,4S)-1-(4-fluorophenyl-2,3,5,6-d4)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone

Synonyms:  Ezetrol-d4

Molecular weight: 413.5

CAS: 1093659-89-2

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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