A cholesterol transport inhibitor; blocks cholesterol absorption in various animal models at 0.0005-0.05 mg/kg

Ezetimibe – 25 mg

Brand:
Cayman
CAS:
163222-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes.{19679,15337,}Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1.{19679,15337} Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.{19679,43023}  

 

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Description

A cholesterol transport inhibitor; blocks cholesterol absorption in various animal models at 0.0005-0.05 mg/kg

Formal name: (3R,4S)-1,4-fluorophenyl-3-[(3S-3-4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone

Synonyms:  Ezetrol|SCH 58235

Molecular weight: 409.4

CAS: 163222-33-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Lipids & Lipoproteins|Storage & Transport||Research Area|Endocrinology & Metabolism|Metabolic Diseases

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