Catalog Shortened Blurb

Exendin-4 (acetate) – 1 mg

Brand:
Cayman
CAS:
914454-01-6
Storage:
-20
UN-No:
Non-Hazardous - /

Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).{27501,27502,27504,24256} By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes.{27502} Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ‘exenatide.’ Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.{27503,27506} Exenatide also has anxiolytic and anti-depressant effects and induces satiety.{27506,27505}  

 

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SKU: 11096 - 1 mg Category:

Description

Catalog Shortened Blurb,A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis,

Formal name:

Synonyms:  Exenatide Acetate

Molecular weight: 4,246.60

CAS: 914454-01-6

Purity: ≥95%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Neuroprotection

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