A potent antagonist of GLP-1R (Kd = 1.7 nM); inhibits exendin-3-induced increases in cAMP levels (IC50 = 20 nM); reverses GLP-1 inhibition of feeding behavior in rats when administered at 10 and 100 µg

Exendin-3 (9-39) amide – 500 µg

Brand:
Cayman
CAS:
133514-43-9
Storage:
-20
UN-No:
Non-Hazardous - /

Exendin-3 (9-39) amide is a truncated form of the exendin-4 (Item No. 11096) peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).{27504} It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM).{34476} Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 µg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.{34477}  

 

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Description

A potent antagonist of GLP-1R (Kd = 1.7 nM); inhibits exendin-3-induced increases in cAMP levels (IC50 = 20 nM); reverses GLP-1 inhibition of feeding behavior in rats when administered at 10 and 100 µg, i.c.v. into the hypothalamus

Formal name:

Synonyms:  Exendin (9-39)

Molecular weight: 3,369.80

CAS: 133514-43-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake

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