A potent inhibitor of ALK5 (IC50 = 12.9 nM); also inhibits ALK2 and ALK4 at nanomolar concentrations; used to block TGF-β signaling and EMT in animal models of cancer and fibrosis

EW-7197 – 5 mg

Brand:
Cayman
CAS:
1352608-82-2
Storage:
-20
UN-No:
Non-Hazardous - /

EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-β receptor type 1; IC50 = 12.9 nM).{34039,34042} It also inhibits ALK2 and ALK4 at nanomolar concentrations.{34042} EW-7197 blocks TGF-β/Smad signaling, cell migration, invasion, and lung metastasis in mouse mammary tumor virus/c-Neu mice and 4TI orthotopic-grafted mice.{34042} It also inhibits epithelial-to-mesenchymal transition (EMT) in TGF-β-treated breast cancer cells.{34042} EW-7197 is used to block TGF-β signaling and EMT in animal models of cancer and fibrosis.{34040,34041,34043}  

 

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Description

A potent inhibitor of ALK5 (IC50 = 12.9 nM); also inhibits ALK2 and ALK4 at nanomolar concentrations; used to block TGF-β signaling and EMT in animal models of cancer and fibrosis

Formal name: N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine

Synonyms: 

Molecular weight: 399.4

CAS: 1352608-82-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ALK (Activin-like Kinase) Signaling||Research Area|Cell Biology|Cell Signaling

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