Description
A partial agonist of α7 subunit-containing nAChRs (IC50 = 22.38 nM); 1,000-fold selective for α7 subunit-containing nAChRs over α4β2 subunit-containing nAChRs at 10 µM, as well as a panel of 60 peptide and nonpeptide receptors, ion channels, and transporters; induces inward currents in Xenopus oocytes expressing human α7 subunit-containing nAChRs (EC50 = 0.16 µM); reverses scopolamine-induced deficits in the novel object recognition task and prevents natural forgetting of a familiar object in rats at 0.1, 0.3, and 1 mg/kg; reduces premature responding in the 5CSRTT in low-attentive female rats
Formal name: N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-7-chloro-benzo[b]thiophene-2-carboxamide, monohydrochloride
Synonyms:
Molecular weight: 357.3
CAS: 550999-74-1
Purity: ≥95%
Formulation: A crystalline solid
