A quassinoid; active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml

Eurycomanone – 5 mg

Brand:
Cayman
CAS:
84633-29-4
Storage:
-20
UN-No:
Non-Hazardous - /

Eurycomanone is a quassinoid originally isolated from E. longifolia that has diverse biological activities.{59000} It is active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml, respectively).{59002} Eurycomanone induces lipolysis in 3T3-L1 adipocytes with an EC50 value of 14.6 µM, an effect that can be blocked by the protein kinase A (PKA) inhibitor H-89 (Item No. 10010556).{59001} It induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells when used at a concentration of 5 µg/ml.{59003} It reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations when used at concentrations of 1 and 10 µM.{59004} Eurycomanone (1 mg/kg, i.p.) decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation.{59005}  

 

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SKU: 30896 - 5 mg Category:

Description

A quassinoid; active against the W2 and D6 clones of P. falciparum (IC50s = 0.015 and 0.026 µg/ml, respectively); induces lipolysis in 3T3-L1 adipocytes (EC50 = 14.6 µM); induces cell cycle arrest at the G2/M phase and apoptosis in HepG2 cells at 5 µg/ml; reduces estrogen release and increases testosterone release in isolated rat Leydig cell-rich testicular interstitial cell preparations at 1 and 10 µM; decreases gastric acid secretion and lesion size in rat models of indomethacin-, water immersion stress-, or pyloric ligation-induced ulcer formation at 1 mg/kg

Formal name: (1β,11β,12α,15β)-11,20-epoxy-1,11,12,14,15-pentahydroxy-picrasa-3,13(21)-diene-2,16-dione

Synonyms:  NSC 339187|Pasakbumin A

Molecular weight: 408.4

CAS: 84633-29-4

Purity: ≥95%

Formulation: A solid

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