A tricyclic diterpene; inhibits early-stage adipogenesis of 3T3-L1 cells at 25 and 50 µM; inhibits proliferation of HL-60 cells in a concentration-dependent manner

Euphorbiasteroid – 250 mg

Brand:
Cayman
CAS:
28649-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

Euphorbiasteroid is a tricyclic diterpene that has been found in the plant E. lathyris.{48442} It inhibits early-stage adipogenesis of 3T3-L1 cells, decreasing intracellular triglyceride accumulation when used at concentrations of 25 and 50 µM.{48443} It decreases the expression of Fas, C/EBPα, PPARγ, and SREBP-1c and increases phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) in 3T3-L1 cells. Euphorbiasteroid inhibits proliferation of HL-60 cells in a concentration-dependent manner, as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells.{48444} It increases P-glycoprotein activity, reverses multi-drug resistance, and restores cytotoxicity of the anticancer agents vinblastine (Item No. 11762), paclitaxel (Item No. 10461), and doxorubicin (Item No. 15007) to MES-SA/Dx5 sarcoma cells.{48445}  

 

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SKU: 27822 - 250 mg Category:

Description

A tricyclic diterpene; inhibits early-stage adipogenesis of 3T3-L1 cells at 25 and 50 µM; inhibits proliferation of HL-60 cells in a concentration-dependent manner, as well as induces apoptosis and increases the expression of Fas and Fas ligand (FasL) and the activity of caspase-3 and caspase-8 in HL-60 cells; increases P-glycoprotein activity, reverses multi-drug resistance, and restores cytotoxicity of vinblastine, paclitaxel, and doxorubicin to MES/SA/Dx5 sarcoma cells

Formal name: benzeneacetic acid, (1aR,2’R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2′-oxiran]-7-yl ester

Synonyms: 

Molecular weight: 552.7

CAS: 28649-59-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Apoptosis

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