A cytotoxic fungal metabolite (IC50s = 0.005 and 0.002 μg/ml for HCT116 and HCTVM46 cells

Eupenifeldin – 500 µg

Brand:
Cayman
CAS:
151803-45-1
Storage:
-20
UN-No:
Non-Hazardous - /

Eupenifeldin is a pentacyclic bistropolone fungal metabolite originally isolated from E. brefeldianum ATCC 74184.{39755} It is cytotoxic against HCT116 and HCTVM46 colon carcinoma cells in vitro (IC50s = 0.005 and 0.002 μg/ml, respectively). In vivo, eupenifeldin (0.3-2 mg/kg per day) increases median survival time in a mouse model of P388 leukemia.  

 

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SKU: 25114 - 500 µg Category:

Description

A cytotoxic fungal metabolite (IC50s = 0.005 and 0.002 μg/ml for HCT116 and HCTVM46 cells, respectively); increases median survival time in a mouse model of P388 leukemia from 0.3-2 mg/kg per day,

Formal name: (6aS,8E,11aR,18aS,19S,20aS)-6a,7,10,11,11a,18a,19,20,20a,21-decahydro-4,16,19-trihydroxy-1,6a,10,10,13,18a-hexamethyl-3H-dicyclohepta[e,e’]cycloundeca[1,2-b:5,6-b’]dipyran-3,15(12H)-dione

Synonyms: 

Molecular weight: 548.7

CAS: 151803-45-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death

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