A flavonoid with diverse biological activities; inhibits cell growth in A375 melanoma cells from 25-800 µM; binds to PPARα (IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα from 10-300 µM; prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells; inhibits 5-LO activity in cultured mastocytoma cells (IC50 = 14 µM); reduces pulmonary edema and levels of the lung injury markers SPA and SPD in a rat model of LPS-induced acute lung injury at 5

Eupatilin – 50 mg

Brand:
Cayman
CAS:
22368-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Eupatilin is a flavonoid that has been found in Artemisia and has diverse biological activities.{31454,31451,31453,61041,61042} It inhibits cell growth in A375 melanoma cells when used at concentrations ranging from 25 to 800 µM.{31454} Eupatilin binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα, but not PPARγ, when used at concentrations ranging from 10 to 300 µM.{31451} It prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells.{31452} Eupatilin also inhibits 5-lipoxygenase (5-LO) activity in cultured mastocytoma cells (IC50 = 14 µM).{31453} In vivo, eupatilin (5, 10, and 15 mg/kg) reduces pulmonary edema and levels of the lung injury markers surfactant protein A (SPA) and SPD in a rat model of LPS-induced acute lung injury.{61041} It reduces serum levels of histamine and increases survival in a mouse model of allergic anaphylactic shock induced by compound 48/80 (Item No. 22173).{61042}  

 

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Description

A flavonoid with diverse biological activities; inhibits cell growth in A375 melanoma cells from 25-800 µM; binds to PPARα (IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα from 10-300 µM; prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells; inhibits 5-LO activity in cultured mastocytoma cells (IC50 = 14 µM); reduces pulmonary edema and levels of the lung injury markers SPA and SPD in a rat model of LPS-induced acute lung injury at 5, 10, and 15 mg/kg; reduces serum levels of histamine and increases survival in a mouse model of compound 48/80-induced allergic anaphylactic shock

Formal name: 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one

Synonyms:  NSC 122413

Molecular weight: 344.3

CAS: 22368-21-4

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

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