A flavonoid with diverse biological activities; inhibits cell growth in A375 melanoma cells from 25-800 µM; binds to PPARα (IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα from 10-300 µM; prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells; inhibits 5-LO activity in cultured mastocytoma cells (IC50 = 14 µM); reduces pulmonary edema and levels of the lung injury markers SPA and SPD in a rat model of LPS-induced acute lung injury at 5

Eupatilin – 25 mg

Brand:
Cayman
CAS:
22368-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Eupatilin is a flavonoid that has been found in Artemisia and has diverse biological activities.{31454,31451,31453,61041,61042} It inhibits cell growth in A375 melanoma cells when used at concentrations ranging from 25 to 800 µM.{31454} Eupatilin binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα, but not PPARγ, when used at concentrations ranging from 10 to 300 µM.{31451} It prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells.{31452} Eupatilin also inhibits 5-lipoxygenase (5-LO) activity in cultured mastocytoma cells (IC50 = 14 µM).{31453} In vivo, eupatilin (5, 10, and 15 mg/kg) reduces pulmonary edema and levels of the lung injury markers surfactant protein A (SPA) and SPD in a rat model of LPS-induced acute lung injury.{61041} It reduces serum levels of histamine and increases survival in a mouse model of allergic anaphylactic shock induced by compound 48/80 (Item No. 22173).{61042}  

 

Available on backorder

Add to quotes
SKU: 19601 - Category:

Description

A flavonoid with diverse biological activities; inhibits cell growth in A375 melanoma cells from 25-800 µM; binds to PPARα (IC50 = 1.18 µM) and induces reporter gene expression in CV-1 cells expressing human PPARα from 10-300 µM; prevents hydrogen peroxide-induced disruption of the F-actin cytoskeleton and inhibition of cell migration in AGS gastric epithelial cells; inhibits 5-LO activity in cultured mastocytoma cells (IC50 = 14 µM); reduces pulmonary edema and levels of the lung injury markers SPA and SPD in a rat model of LPS-induced acute lung injury at 5, 10, and 15 mg/kg; reduces serum levels of histamine and increases survival in a mouse model of compound 48/80-induced allergic anaphylactic shock

Formal name: 2-(3,4-dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one

Synonyms:  NSC 122413

Molecular weight: 344.3

CAS: 22368-21-4

Purity: ≥98%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity

Related products

  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page