A salen-manganese complex with catalase and SOD mimetic activity

EUK 134 – 10 mg

Brand:
Cayman
CAS:
81065-76-1
Storage:
-20
UN-No:
Non-Hazardous - /

Synthetic manganese-porphyrin complexes have been documented to act as scavengers for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro.{12345} EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid.{12346}  

 

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SKU: 10006329 - 10 mg Category:

Description

A salen-manganese complex with catalase and SOD mimetic activity

Formal name: chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese

Synonyms: 

Molecular weight: 416.7

CAS: 81065-76-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Catalase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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