A bicyclic monoterpene; inhibits ionomycin- and PMA-induced TNF-α

Eucalyptol – 100 mg

Brand:
Cayman
CAS:
470-82-6
Storage:
-20
UN-No:
Limited Quantity - 1993 / 3

Eucalyptol is a bicyclic monoterpene that has been found in Eucalyptus and other plants, including C. sativa and has diverse biological activities, including anti-inflammatory, decongestant, antinociceptive, and insect repellent properties.{21071,39875,39876,39877,39878} Eucalyptol (10 μM) inhibits TNF-α, IL-1β, IL-4, and IL-5 production by primary human lymphocytes stimulated by ionomycin (Item No. 10004974) and phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{39875} It also decreases LPS-induced mucus production by primary human nasal turbinate slices when used at a concentration of 10 μM.{39876} Eucalyptol (400 mg/kg) decreases carrageenan-induced hind paw edema in rats and reduces the time spent licking the hind paw in a formalin-induced nociception test in mice.{39877} It inhibits A. aegypti mosquitoes from feeding on anesthetized gerbils when applied topically at a concentration of 10% and from laying eggs in an ovipositional bioassay when used at a concentration of 1% in standing water.{39878} Formulations containing eucalyptol have been used in mouthwash and cough suppressants.  

 

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Description

A bicyclic monoterpene; inhibits ionomycin- and PMA-induced TNF-α, IL-1β, IL-4, and IL-5 production by primary human lymphocytes at 10 μM; decreases LPS-induced mucus production by primary human nasal turbinate slices at 10 μM; decreases carrageenan-induced hind paw edema in rats and reduces the time spent licking the hind paw in a formalin-induced nociception test in mice at 400 mg/kg; inhibits A. aegypti mosquitoes from feeding on anesthetized gerbils when applied topically at 10% and from laying eggs in an ovipositional bioassay at 1% in standing water,

Formal name: 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane

Synonyms:  NSC 6171

Molecular weight: 154.3

CAS: 470-82-6

Purity: ≥98%

Formulation: A neat oil

Application||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Pain Research

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