An NNRTI; active against the wild-type HIV-1 strains LAI

Etravirine – 10 mg

Brand:
Cayman
CAS:
269055-15-4
Storage:
-20
UN-No:
Non-Hazardous - /

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).{32936} It is active against the wild-type HIV-1 strains LAI, SF2, and Ba-L (EC50s = 1.4-4.8 nM) but not the HIV-2 strain ROD (EC50 = 3,479 nM). Etravirine is also active against 18 HIV-1 strains carrrying NNRTI resistance-associated mutations (EC50s = <5 nM). Etravirine (5 μM) increases intracellular processing of the viral polyproteins Gag and Gag-Pol and decreases viral particle production in HEK293T cells transfected with a plasmid encoding the NL4.3 infectious molecular clone of HIV-1.{32937} Formulations containing etravirine have been used in the treatment of HIV-1 infection.  

 

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Description

An NNRTI; active against the wild-type HIV-1 strains LAI, SF2, and Ba-L (EC50s = 1.4-4.8 nM) but not the HIV-2 strain ROD (EC50 = 3,479 nM); active against 18 HIV-1 strains carrying NNRTI resistance-associated mutations (EC50s = <5 nM for all); increases intracellular processing of the viral polyproteins Gag and Gag-Pol and decreases viral particle production in HEK293T cells transfected with a plasmid encoding the NL4.3 infectious molecular clone of HIV-1 at 5 μM

Formal name: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile

Synonyms:  R165335|TMC125

Molecular weight: 435.3

CAS: 269055-15-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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