A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1

Etoricoxib – 10 mg

Brand:
Cayman
CAS:
202409-33-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Etoricoxib is a dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1 in several assays, e.g., in the production of PGE2 by CHO cells expressing either COX-2 (IC50 = 79 nM) or COX-1 (IC50 > 50 µM).{11268,15425} Oral etoricoxib is well absorbed and metabolized extensively via oxidation, with metabolites excreted largely in the urine.{12837}  

 

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SKU: 10091 - 10 mg Category:

Description

A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1

Formal name: 5-chloro-6′-methyl-3-[4-(methylsulfonyl)phenyl]-2,3′-bipyridine

Synonyms:  L-791,456|MK-0663

Molecular weight: 358.8

CAS: 202409-33-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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