Description
An inhibitor of topoisomerase II (IC50 = 60.3 µM); inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and HUVEC cells (IC50 = 0.249 µM); reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model at 25 mg/kg, an effect enhanced by cyclosporin A; inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).
Formal name: (5aR)-9S-[[4,6-O-ethylidene-β-D-glucopyranosyl]oxy]-5R,8,8aR,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1R,3-dioxol-6(5aH)-one
Synonyms: EPE|NSC 141540|VP-16-123
Molecular weight: 588.6
CAS: 33419-42-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|DNA Damage and Repair|Topoisomerase
