An inhibitor of topoisomerase II (IC50 = 60.3 µM); inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12

Etoposide – 25 mg

Brand:
Cayman
CAS:
33419-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

Etoposide is a plant alkaloid and an inhibitor of topoisomerase II (IC50 = 60.3 μM).{21619,21623} It inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and human umbilical vein endothelial (HUVEC) cells (IC50 = 0.249 µM).{21620} It reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model when administered at a dose of 25 mg/kg, an effect that is enhanced by concomitant administration of the immunosuppressant cyclosporin A (Item No. 12088).{47188} Etoposide also inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).{21622} Formulations containing etoposide have been used in combination therapy in the treatment of cancer.  

 

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SKU: 12092 - 25 mg Category:

Description

An inhibitor of topoisomerase II (IC50 = 60.3 µM); inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and HUVEC cells (IC50 = 0.249 µM); reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model at 25 mg/kg, an effect enhanced by cyclosporin A; inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM).

Formal name: (5aR)-9S-[[4,6-O-ethylidene-β-D-glucopyranosyl]oxy]-5R,8,8aR,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1R,3-dioxol-6(5aH)-one

Synonyms:  EPE|NSC 141540|VP-16-123

Molecular weight: 588.6

CAS: 33419-42-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|DNA Damage and Repair|Topoisomerase

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