An NSAID and diethylene glycol ester form of flufenamic acid; inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and production of PGE2 in stimulated rat peritoneal macrophages; reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg

Etofenamate – 250 mg

Brand:
Cayman
CAS:
30544-47-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) and diethylene glycol ester form of flufenamic acid (Item No. 21447) that has anti-inflammatory and analgesic activities.{41244,41245} It inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and the production of prostaglandin E2 (PGE2; Item No. 14010) in stimulated rat peritoneal macrophages.{41245} In vivo, etofenamate reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively.{41244} Etofenamate (40 mg/kg per day for 21 days) inhibits inflammation in a rat model of adjuvant-induced arthritis. It also decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity. Formulations containing etofenamate have been used in the treatment of osteoarthritis.  

 

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SKU: 23674 - 250 mg Category:

Description

An NSAID and diethylene glycol ester form of flufenamic acid; inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and production of PGE2 in stimulated rat peritoneal macrophages; reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively; inhibits inflammation in a rat model of adjuvant-induced arthritis; decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity

Formal name: 2-[[3-(trifluoromethyl)phenyl]amino]-benzoic acid, 2-(2-hydroxyethoxy)ethyl ester

Synonyms: 

Molecular weight: 369.3

CAS: 30544-47-9

Purity: ≥98%

Formulation: A neat oil

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Pain Research

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