Description
A positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors; selectively increases GABA-induced currents in X. laevis oocytes expressing α1β2γ2 or α1β3γ2 over α1β1γ2 subunit-containing receptors at 20 µM; inhibits muscimol binding in rat corticol membranes (Kd = 23 nM in a radioligand binding assay); increases NGF-induced neurite outgrowth in PC12 cells at 20 µM; increases the percentage of time spent in the open arms of the elevated plus maze in high-anxiety BALB/cByJ, but not C57BL/6, mice at 12.5 mg/kg; increases the seizure threshold in a mouse model of seizures induced by picrotoxin (MED = 75 mg/kg); increases the paw withdrawal threshold on the ipsilateral side in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant at 50 mg/kg
Formal name: 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3, 1-benzoxazin-2-amine
Synonyms: Etafenoxine|HOE 36-801
Molecular weight: 300.8
CAS: 21715-46-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Seizure Disorders
