A D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors

Eticlopride (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
97612-24-3
Storage:
-20
UN-No:
Non-Hazardous - /

Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively).{45603} It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind α1-adrenergic receptors (α1-ARs; IC50 = 110 nM) in radioligand binding assays.{45604} Eticlopride (10 μg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT).{45605} It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 μg/kg, respectively.  

 

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SKU: 29112 - 5 mg Category:

Description

A D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively); selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, α2-adrenergic, and β-adrenergic, Histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as 5-HT1 and 5-HT2 receptors (IC50s = 6,200 and 830, respectively) in radioligand binding assays; binds α1-ARs (IC50 = 110 nM); inhibits 7-OH-DPAT-induced stereotyped behavior in rats at 10 μg/kg; inhibits inhibits ketamine- and cocaine-induced hypermotility in rats at 20 and 50 μg/kg, respectively

Formal name: 3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-benzamide, monohydrochloride

Synonyms:  (−)-Eticlopride|S-(−)-Eticlopride

Molecular weight: 377.3

CAS: 97612-24-3

Purity: ≥98%

Formulation: A crystalline solid

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