A nucleoside analog with anticancer activity; cytotoxic to A549

Ethynylcytidine – 5 mg

Brand:
Cayman
CAS:
180300-43-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ethynylcitidine (ECyD) is a nucleoside analog with anticancer activity.{55062,55061} It is cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively).{55062} ECyD (0.25 mg/kg per day) reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models.{55061}  

 

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Description

A nucleoside analog with anticancer activity; cytotoxic to A549, NUGC-3, HT-29, MIA PaCa-2, and MCF-7 cancer cells (IC50s = 0.114, 1.032, 0.539, 0.198, and 0.326 µM, respectively); reduces tumor growth in CADO-LC11 lung, PAN-12 pancreas, AZ-521 stomach, and CO-3 colon cancer mouse xenograft models at 0.25 mg/kg per day

Formal name: 3′-C-ethynyl-cytidine

Synonyms:  1-(3-C-Ethynyl-β-D-ribofuranosyl)cytosine|ECyD|TAS-106

Molecular weight: 267.2

CAS: 180300-43-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Cancer|Cell Death

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