A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM

Ethyl p-methoxycinnamate – 50 mg

Brand:
Cayman
CAS:
24393-56-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities.{36073,36074,36075,36076} It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo.{36075,36076} EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats.{36076} It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.{36073,36074}  

 

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SKU: 11740 - 50 mg Category:

Description

A natural product with diverse actions; inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively); reduces IL-1 and TNF-a production in vivo; inhibits granuloma tissue formation in a dose-dependent manner in rats; inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml); reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum; larvicidal (LC50 = 53.64 ppm) against Ae. aegypti,

Formal name: 3-(4-methoxyphenyl)-2E-propenoic acid, ethyl ester

Synonyms:  EPMC|Ethyl para-methoxycinnamate|Ethyl 4-methoxycinnamate

Molecular weight: 206.2

CAS: 24393-56-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Pain Research||Research Area|Toxicology|Environmental

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