A modestly selective NOS inhibitor with Ki values for inhibition of nNOS

Ethyl-L-NIO (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
150403-97-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 µM, respectively, as determined using initial rate measurements.{6358} However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively).{6358} Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2.{6358}  

 

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SKU: 10012088 - 100 mg Category:

Description

A modestly selective NOS inhibitor with Ki values for inhibition of nNOS, eNOS, and iNOS of 5.3, 18, and 12 µM, respectively; however, does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 µM, respectively)

Formal name: N5-(1-iminobutyl)-L-ornithine, monohydrochloride

Synonyms:  L-N5-(1-Iminobutyl)ornithine hydrochloride

Molecular weight: 237.7

CAS: 150403-97-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Nitric Oxide Synthases||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|eNOS||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|iNOS||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|nNOS

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