Description
An internal standard for the quantification of estrone by GC- or LC-MS
Formal name: 3-hydroxy-estra-1,3,5(10)-trien-17-one-2,4-d2
Synonyms: E1-d2
Molecular weight: 272.4
CAS: 350820-16-5
Purity: ≥98%
Formulation: A crystalline solid
Estrone-d2 – 500 µg
Brand:
Cayman
CAS:
350820-16-5
Storage:
-20
UN-No:
Non-Hazardous - /
Estrone-d2 is intended for use as an internal standard for the quantification of estrone (Item Nos. ISO60165 | 10006485) by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol (Item Nos. ISO60155 | 10006315) and estriol (Item Nos. ISO60164 | 10006484).{9611} Estrone is synthesized from androstenedione (Item No. ISO60161) by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.{9611,8343} Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.{9611} The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.{9611}
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