Description
Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily of transcription factors encoded by ESR1 in humans that has a key role in reproductive function and additional roles in cancer progression and inhibition.{59658,59659,59660} Alternative splicing of the ESR1 pre-mRNA produces one full-length 66 kDa isoform and two short-length 46 and 36 kDa isoforms, which contain truncated C-termini.{59660} ERα is comprised of an N-terminal domain that contains AF-1, which is critical for the transactivation function of ERα, a DNA binding domain that recognizes estrogen response elements (EREs) on target genes, and a C-terminal ligand binding domain (LBD) that contains the nuclear localization signal.{59659,59658} ERα is widely expressed in numerous tissues, including breast, prostate, uterus, liver, and bone, and localizes to the cytoplasm in a complex with heat shock protein 90 (Hsp90).{59660,59659} Upon estrogen stimulation, ERα dissociates from Hsp90, dimerizes, and translocates to the nucleus, where it binds EREs expressed by target genes encoding proteins that activate numerous signaling pathways, including ERK/MAPK, PI3K/Akt/mTOR, and NF-κB, and influence a variety of cellular processes, including reproductive function, bone homeostasis, and inflammation, as well as tumor progression and metastasis.{59659,59658} ERα is overexpressed in more than 50% of patients with breast cancer, but is associated with improved prognosis, whereas loss of ERα is a feature of triple-negative breast cancer (TNBC) and is associated with resistance to hormonal therapy.{59661} Cayman’s Estrogen Receptor α Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
Synonyms:
Immunogen: Peptide corresponding to a region near the N-terminus of human ERα
Formulation: 100 µl protein A-purified monoclonal antibody
Isotype: IgG
Applications: IHC, WB
Origin:
Stability: 365 days
Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Multidrug Resistance||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation
