A metabolite of estriol; binds to basolateral and canalicular liver plasma membranes (Kds = 85 and 164 µM

Estriol 3-β-D-Glucuronide (sodium salt) – 5 mg

Brand:
Cayman
CAS:
15087-06-6
Storage:
-20
UN-No:
Non-Hazardous - /

Estriol 3-β-D-glucuronide is a metabolite of estriol (Item No. 10006484).{43880} It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 µM, respectively.{43881} It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide (4Mu-GlcU; Item No. 17203) and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).{14585}  

 

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Description

A metabolite of estriol; binds to basolateral and canalicular liver plasma membranes (Kds = 85 and 164 µM, respectively); competitively inhibits 4Mu-GlcU hydrolysis and is a substrate for hydrolysis by KLFc

Formal name: 16α,17β-dihydroxyestra-1,3,5(10)-trien-3-yl, β-D-glucopyranosiduronic acid, monosodium salt

Synonyms:  Estriol sodium 3-glucuronate

Molecular weight: 487.5

CAS: 15087-06-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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