A derivative of estradiol that destabilizes microtubules (Kds = 10 and 15 µM for MAP-1 and MAP-2

Estramustine Phosphate (sodium salt) – 50 mg

Brand:
Cayman
CAS:
52205-73-9
Storage:
-20
UN-No:
Non-Hazardous - /

Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 | 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 µM for MAP-1 and MAP-2, respectively.{41153} Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells.{41150,41151} The metabolites of estramustine phosphate have anti-androgenic effects.{41152} Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.  

 

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Description

A derivative of estradiol that destabilizes microtubules (Kds = 10 and 15 µM for MAP-1 and MAP-2, respectively); induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells; induces apoptosis in U87MG human malignant glioma cells

Formal name: estra-1,3,5(10)-triene-3,17-diol (17β)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt

Synonyms:  Ro 21-8837/001

Molecular weight: 564.4

CAS: 52205-73-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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