A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2

Estradiol 3-(β-D-Glucuronide) (sodium salt) – 1 mg

Brand:
Cayman
CAS:
14982-12-8
Storage:
-20
UN-No:
Non-Hazardous - /

Estradiol 3-(β-D-glucuronide) (E23G) is a non-cholestatic regioisomer of the estrogen metabolite, estradiol 17-(β-D-glucuronide) (E217G; Item No. 16156).{26342,26341} It acts as a substrate for multidrug resistance protein 2 (MRP2; Km = 122 µM), competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM).{26341,26340} E23G has been reported to inhibit E217G transport through rat organic anion-transporting polypeptide 1 with a Ki value of 9.7 µM, but is a low-affinity inhibitor of both MRP4 and MRP7 (IC50s = ~ 100 µM).{26341}  

 

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Description

A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC50 = 14.2 µM)

Formal name: (17β)-17-hydroxyestra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronic acid, monosodium salt

Synonyms:  17β-Estradiol 3-(β-D-Glucuronide)|17β-Oestradiol 3-(β-D-Glucuronide)|E23G|β-Estradiol 3-(β-D-Glucuronide)

Molecular weight: 470.5

CAS: 14982-12-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Transporter & Exchanger Modulators||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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