Description
A coumarin with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 4 and 2.5 µM, respectively), as well as JARID1B (IC50 = 4.6 µM); active against B. cereus, S. lutea, S. aureus, S. lactis, A. faecalis, and E. coli; reduces LRRK2G2019S-induced production of hydrogen peroxide in Drosophila brain lysates and decreases cell death in LRRK2G2019S-expressing primary human cortical neurons; reduces croton oil-induced ear edema in mice at 1.68 µmol/ear; inhibits acetylcholine-induced writhing in mice (ED50 = 69 mg/kg)
Formal name: 6,7-dihydroxy-2H-1-benzopyran-2-one
Synonyms: 6,7-Dihydroxycoumarin|Aesculetin|Cichorigenin|NSC 26427
Molecular weight: 178.1
CAS: 305-01-1
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen
