A coumarin with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 4 and 2.5 µM

Esculetin – 1 g

Brand:
Cayman
CAS:
305-01-1
Storage:
22
UN-No:
Non-Hazardous - /

Esculetin is a coumarin that has been found in Euphorbia and has diverse biological activities.{652,27801,57262,31766,57263} It inhibits 5-lipoxygenase (5-LO) and 12-LO (IC50s = 4 and 2.5 µM, respectively), as well as the histone demethylase jumonji AT-rich interactive domain 1B (JARID1B; IC50 = 4.6 µM).{652,27801} Esculetin is active against B. cereus, S. lutea, S. aureus, S. lactis, A. faecalis, and E. coli.{57262} It reduces production of hydrogen peroxide induced by the leucin-rich repeat kinase 2 (LRRK2) mutant LRRK2G2019S, which is linked to neurotoxicity and Parkinson’s disease, in Drosophila brain lysates and decreases cell death in LRRK2G2019S-expressing primary human cortical neurons.{31766} Esculetin (1.68 µmol/ear) reduces croton oil-induced ear edema in mice.{57263} It also inhibits acetylcholine-induced writhing in mice (ED50 = 69 mg/kg).  

 

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Description

A coumarin with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 4 and 2.5 µM, respectively), as well as JARID1B (IC50 = 4.6 µM); active against B. cereus, S. lutea, S. aureus, S. lactis, A. faecalis, and E. coli; reduces LRRK2G2019S-induced production of hydrogen peroxide in Drosophila brain lysates and decreases cell death in LRRK2G2019S-expressing primary human cortical neurons; reduces croton oil-induced ear edema in mice at 1.68 µmol/ear; inhibits acetylcholine-induced writhing in mice (ED50 = 69 mg/kg)

Formal name: 6,7-dihydroxy-2H-1-benzopyran-2-one

Synonyms:  6,7-Dihydroxycoumarin|Aesculetin|Cichorigenin|NSC 26427

Molecular weight: 178.1

CAS: 305-01-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Coumarins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection||Research Area|Neuroscience|Pain Research||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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