A potential impurity in commercial preparations of erythromycin; a precursor in the synthesis of clarithromycin

Erythromycin A N-oxide – 5 mg

Brand:
Cayman
CAS:
992-65-4
Storage:
-20
UN-No:
Non-Hazardous - /

Erythromycin A N-oxide is a potential impurity found in commercial preparations of erythromycin.{35178} Erythromycin (Item No. 16486) is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{22680} It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l).{22758} Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications.{22760,17924} Erythromycin A N-oxide is also a precursor in the synthesis of clarithromycin (Item No. 19455).{35220}  

 

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Description

A potential impurity in commercial preparations of erythromycin; a precursor in the synthesis of clarithromycin

Formal name: erythromycin N-oxide

Synonyms: 

Molecular weight: 749.9

CAS: 992-65-4

Purity: ≥98%

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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