A macrolide antibiotic; inhibits 50S ribosome activity; active against a host of bacterial genera

Erythromycin – 5 g

Brand:
Cayman
CAS:
114-07-8
Storage:
-20
UN-No:
Non-Hazardous - /

Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.{22680} It is active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l).{22758} Erythromycin (10-40 mg/kg) dose-dependently inhibits the growth of S. aureus in a mouse model of thigh infection.{42209} It also inhibits the cytochrome P450 (CYP450) isoform CYP3A4 in vitro with IC50 values of 33 and 27.3 µM for α-hydroxytriazolam and 4-hydroxytriazolam formation, respectively, following administration of triazolam, which is known to be metabolized primarily by CYP3A4.{22760,42210} Formulations containing erythromycin have been used in the treatment of bacterial respiratory and skin infections, pertussis, and a variety of other bacterial infections.  

 

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Description

A macrolide antibiotic; inhibits 50S ribosome activity; active against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l); dose-dependently inhibits the growth of S. aureus in a mouse model of thigh infection at 10-40 mg/kg; inhibits CYP3A4 (IC50s = 33 and 27.3 µM for α-hydroxytriazolam and 4-hydroxytriazolam formation, respectively)

Formal name: erythromycin

Synonyms:  NSC 55929

Molecular weight: 733.9

CAS: 114-07-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pertussis

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