An ERG inhibitor (IC50 = 315 nM); inhibits proliferation of ERG-expressing VCaP prostate

ERGi-USU – 500 mg

Brand:
Cayman
CAS:
1147-56-4
Storage:
-20
UN-No:
Non-Hazardous - /

ERGi-USU is an inhibitor of the oncoprotein ETS-related gene (ERG; IC50 = 315 nM).{52670} It inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but not LNCaP, LAPC4, and MDA PCa 2b prostate cancer and human umbilical vein endothelial cells (HUVECs), which do not express ERG (IC50s = >10 µM for all). ERGi-USU (100 and 150 mg/kg) reduces tumor growth in a VCaP mouse xenograft model.  

 

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SKU: 30875 - 500 mg Category:

Description

An ERG inhibitor (IC50 = 315 nM); inhibits proliferation of ERG-expressing VCaP prostate, COLO 320 colon, and KG-1 and MOLT-4 leukemia cancer cells (IC50s = 30-400 nM) but LNCaP, LAPC4, and MDA PCa 2b prostate cancer and HUVECs, which do not express ERG (IC50s = >10 µM for all); reduces tumor growth in a VCaP mouse xenograft model at 100 and 150 mg/kg

Formal name: 1-[2-(2-thiazolyl)diazenyl]-2-naphthalenol

Synonyms:  NSC 139021

Molecular weight: 255.3

CAS: 1147-56-4

Purity: ≥98%

Formulation: A solid

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