An ERβ agonist (IC50s = 5.4

ERB 041 – 10 mg

Brand:
Cayman
CAS:
524684-52-4
Storage:
-20
UN-No:
Non-Hazardous - /

ERB 041 is an estrogen receptor β (ERβ) agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively).{53106} It is selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for human, rat, and mouse ERα, respectively). ERB 041 induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM). In vivo, ERB 041 (0.1 and 0.3 mg/kg) inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease. It reduces joint swelling in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. ERB 041 (10 mg/kg) also reduces lesion formation in a mouse model of endometriosis.{53107}  

 

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SKU: 28737 - 10 mg Category:

Description

An ERβ agonist (IC50s = 5.4, 3.1, and 3.7 nM for the human, rat, and mouse receptors, respectively); selective for ERβ over ERα (IC50s = 1,200, 620, and 750 nM for the human, rat, and mouse ERα, respectively); induces IGFBP4 mRNA expression in Saos-2 cells expressing human ERβ (EC50 = 20 nM); inhibits chronic diarrhea and reduces colonic ulceration, inflammation, and fibrosis in the HLA-B27 transgenic rat model of inflammatory bowel disease at 0.1 and 0.3 mg/kg; reduces joint swelling in a rat model of adjuvant-induced arthritis at 1 mg/kg; reduces lesion formation in a mouse model of endometriosis at 10 mg/kg

Formal name: 7-ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol

Synonyms: 

Molecular weight: 271.2

CAS: 524684-52-4

Purity: ≥95%

Formulation: A crystalline solid

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