A ferroptosis inducer; induces ferroptotic cell death in vitro

Erastin – 50 mg

Brand:
Cayman
CAS:
571203-78-6
Storage:
-20
UN-No:
Non-Hazardous - /

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer.{43340} It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Item No. 10011659), ferrostatin-1 (Item No. 17729), U-0126 (Item No. 70970), cycloheximide (Item No. 14126), and β-mercaptoethanol. Erastin (5 µM) inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells and inhibits glutamate release in an enzyme-coupled fluorescence assay (EC50 = 1.2 µM). It also selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml).{28833}  

 

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Description

A ferroptosis inducer; induces ferroptotic cell death in vitro, an effect that can be blocked by ferroptosis inhibitors; inhibits cystine uptake by the system xc- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells at 5 µM; inhibits glutamate release via the cystine-glutamate transporter in an enzyme-coupled fluorescence assay (EC50 = 1.2 µM); selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC50s = 1.25-5 µg/ml)

Formal name: 2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

Synonyms: 

Molecular weight: 547.1

CAS: 571203-78-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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