A sensitive fluorescent substrate for sEH that can be used to monitor the activity of both human and mouse enzymes

Epoxy Fluor 7 – 50 mg

Brand:
Cayman
CAS:
863223-43-2
Storage:
-20
UN-No:
Non-Hazardous - /

Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.{12607} Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.{14065,14072} Epoxy fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used to monitor the activity of both human and mouse enzymes.{14078} Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-fold better sensitivity than previously used colorimetric substrates such as NEPC.{14078}  

 

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SKU: 10008610 - 50 mg Category:

Description

A sensitive fluorescent substrate for sEH that can be used to monitor the activity of both human and mouse enzymes

Formal name: cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester, carbonic acid

Synonyms: 

Molecular weight: 389.4

CAS: 863223-43-2

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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