A macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells

Epothilone B – 5 mg

Brand:
Cayman
CAS:
152044-54-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis.{19711,19713} It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively).{19711} Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.{19714}  

 

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SKU: 10924 - 5 mg Category:

Description

A macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis; induces mitotic arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer

Formal name: 7S,11S-dihydroxy-8,8,10R,12S,16R-pentamethyl-3S-[(1E)-1S-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Synonyms:  Epo B

Molecular weight: 507.7

CAS: 152044-54-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Multidrug Resistance||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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